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KMID : 0360220170580060640
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Journal of the Korean Ophthalmological Society
2017 Volume.58 No. 6 p.640 ~ p.645
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Clinical Significance of Tear Film Osmolarity for Non-Sjogren Dry Eye Diagnosis
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Yun Jun-Myeong
Yim Hye-Bin
Kim Hyun-Seung
Na Kyung-Sun
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Abstract
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Purpose: To evaluate the diagnostic value of tear film osmolarity for non-Sjogren dry eye syndrome through measuring the correlation between tear osmolarity and several conventional dry eye parameters.
Methods: In this observational cross-sectional study, 274 patients (274 eyes) with non-Sjogren dry eye syndrome were examined using tear film osmolarity and the following conventional dry eye parameters: Schirmer’s test, tear film break-up time, ocular surface disease index (OSDI), and corneal staining score. The correlations between tear film osmolarity and each conventional dry eye parameter were assessed using Spearman’s correlation coefficients.
Results: The mean tear film osmolarity of the study population was 296.34 ± 21.08 mOsm/L. The tear film osmolarity was significantly negatively correlated with the Schirmer’s test value (r = -0.431, p < 0.001) and tear break-up time (r = -0.131, p = 0.031), while it was significantly positively correlated with the OSDI scores (r = 0.191, p = 0.001) and corneal staining scores (r = 0.150, p = 0.013).
Conclusions: Tear film instability was significantly correlated with other conventional dry eye parameters. However, additional studies are required to determine its feasibility as a stand-alone diagnostic tool.
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KEYWORD
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Non-sjogren dry eye, Schirmer’s test, Tear film osmolarity
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